Morphological Observation of a Process of Bone Marrow Hypoplastic Formation in a Case of Aplastic Anemia
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- UTSUGISAWA Taiju
- Hematology Devision, School of Medicine, Iwate Medical University
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- ONO Yohko
- Hematology Devision, School of Medicine, Iwate Medical University
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- SUGAWARA Takeshi
- Hematology Devision, School of Medicine, Iwate Medical University
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- NUMAOKA Hideharu
- Hematology Devision, School of Medicine, Iwate Medical University
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- SHIMOSEGAWA Kenji
- Hematology Devision, School of Medicine, Iwate Medical University
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- ITO Shigeki
- Hematology Devision, School of Medicine, Iwate Medical University
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- MURAI Kazunori
- Hematology Devision, School of Medicine, Iwate Medical University
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- NARIGASAWA Yasushi
- Hematology Devision, School of Medicine, Iwate Medical University
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- MIYAIRI Yasuro
- Hematology Devision, School of Medicine, Iwate Medical University
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- ITO Toshiharu
- Hematology Devision, School of Medicine, Iwate Medical University
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- ISHIDA Yoji
- Hematology Devision, School of Medicine, Iwate Medical University
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- KURIYA Shin-ichiro
- Hematology Devision, School of Medicine, Iwate Medical University
Bibliographic Information
- Other Title
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- 再生不良性貧血における骨髄低形成成立過程の形態的観察
- サイセイ フリョウセイ ヒンケツ ニ オケル コツズイ テイ ケイセイ セイリ
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Abstract
Bone marrow morphological change was consecutively analyzed from the disease onset to the formation of bone marrow aplasia in a patient with post-hepatitic aplastic anemia. In this case, the mean bone marrow cellularity and absolute numbers of erythroids and megakaryocytes were continuously higher than those in normal subjects for 3 weeks after the appearance of peripheral pancytopenia. During this stage, administration of recombinant human granulocyte colony-stimulating factor (G-CSF) improved marrow myeloid hypoplasia and peripheral neutropenia. During the period in which the marrow cellularity transformed from hyperplasia to hypoplasia, the bone marrow showed a mixtrue of hyper-, normo- and hypocellular portions, and the decrease in the megakaryocytes was the faster than myeloid and erythroid cells. These findings indicate that (1) ineffective hematopoiesis might be present in the early stage of the disease, (2) G-CSF responsive granulocytic precursors remained during the early stage of the disease, and (3) the marrow aplasia progressed in the manner of aplastic nest formation during the period in which the marrow cellularity declined to hypoplasia. We experienced another case of aplastic anemia showing the same progress of bone marrow findings and speculated that this might be one of the ways of the progression of bone marrow hypoplastic formation in aplastic anemia.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 36 (10), 1157-1162, 1995
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390282680003864064
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- NII Article ID
- 10005899250
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DyaK28%2FnsFSrsA%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 3645383
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- PubMed
- 8531324
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed