Clinical Toxicity at the Infusion of Cryopreserved and Thawed Peripheral Blood Stem Cell Grafts in Children

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  • 小児癌患者における自家末梢血幹細胞輸注に伴う副作用の検討
  • ショウニ ガン カンジャ ニ オケル ジカ マッショウケツ カンサイボウ ユチ

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Abstract

To test the safety of infusing cryopreserved and thawed peripheral blood stem cells (PBSC) in children, toxicity assessment was made at 36 infusions in 33 children with various types of cancer. The mean volume of PBSC graft infused was 224 ml (range, 46∼500 ml) or 8.0 ml/kg (1.7∼23.8 ml/kg), in containing 10% dimethylsulfoxide (DMSO). Vomiting was the only toxic feuture related to the amount of DMSO. However, eight patients developed transient shock, put recovered shortly afterward with or without supportive therapy. Attention should be drawn to increased risk in children receiving thawed blood cell grafts.

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  • Rinsho Ketsueki

    Rinsho Ketsueki 33 (3), 317-321, 1992

    The Japanese Society of Hematology

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