Clinical Significance of Soluble Interleukin-2 Receptor in Multiple Myeloma
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- AKIMOTO Yoshihisa
- Department of Hematology, Showa University School of Medicine
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- ISHIYAMA Taijiro
- Department of Hematology, Showa University School of Medicine
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- UENO Hideyuki
- Department of Hematology, Showa University School of Medicine
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- HINO Ken-ichiro
- Department of Hematology, Showa University School of Medicine
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- TOMOYASU Shigeru
- Department of Hematology, Showa University School of Medicine
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- TSURUOKA Nobuyoshi
- Department of Hematology, Showa University School of Medicine
Bibliographic Information
- Other Title
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- 多発性骨髄腫における血中可溶性interleukin-2受容体の臨床的意義
- タハツセイ コツズイシュ ニ オケル ケッチュウ カヨウセイ interleu
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Abstract
Increased levels of soluble interkeukin-2 receptor (sIL-2R) have been noted in the sera of patients with various diseases such as adult T cell leukemia, malignant lymphoma and autoimmune diseases. Using an enzyme-linked immunoabsorbent assay, we assessed sIL-2R levels in the sera of 16 patients with multiple myeloma (MM) and 27 normal subjects. There was a significant increase in the levels of sIL-2R in the patients with myeloma (963±523 U/ml) compared to normal subjects (213±80 U/ml). The levels of sIL-2R corresponded well with the clinical stage, M-protein, serum IL-6 and serum β2 microglobulin levels. Taking the evidence that the CD4/CD8 ratio decreased as the disease worsened into consideration, the increase in the serum sIL-2R levels of the patients with MM is considered to have some correlation with B and T cell activation through various cytokines including IL-6. Furthermore such evidence would support the role of sIL-2R as a disease monitor of MM.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 36 (11), 1247-1251, 1995
The Japanese Society of Hematology
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Details 詳細情報について
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- CRID
- 1390282680004116096
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- NII Article ID
- 10005899444
- 10006175043
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- NII Book ID
- AN00252940
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- COI
- 1:STN:280:DyaK283jsFenug%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 3645590
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- PubMed
- 8691563
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed