Successful Treatment of Splenomegaly and Anemia by VP Therapy in Idiopathic Myelofibrosis Complicated with Acromegaly: A Case Report.

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  • IMAI Yasushi
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • AKIYAMA Nobu
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • HANAZONO Yutaka
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • INAMORI Ken
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • MITANI Kinuko
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • HIRAI Hisamaru
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • NAGAI Ryozo
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo
  • YAZAKI Yoshio
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo

Bibliographic Information

Other Title
  • 先端巨大症を合併し，ＶＰ療法にてひ腫と貧血が改善した特発性骨髄線維症
  • 先端巨大症を合併し,VP療法にて脾腫と貧血が改善した特発性骨髄線維症
  • センタン キョダイショウ オ ガッペイシ VP リョウホウ ニテ ヒ シュ ト

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Description

Here we report a 65-year-old male patient with idiopathic myelofibrosis (IMF) accompanied with acromegaly. He was admitted because of anemia and splenomegaly. No favorable effects were observed when hydroyurea was administered. However, his symptoms were successfully treated by administration of vincristine and prednisolone (VP therapy), which is usually applied for choronic myelogenous leukemia in the accelerated phase. Therefore, VP therapy might be one possible for IMF. Since there have been several reports suggesting the possible association of hematological malignancies with acromegaly, we speculate that acromegaly was implicated in the initiation or progression of IMF in this case.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (10), 1233-1236, 1995

    The Japanese Society of Hematology

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