Prostaglandin E<sub>1</sub> Bladder Instillations for Late-Onset Hemorrhagic Cystitis Following Allogeneic Bone Marrow Transplantation

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  • NAKASEKO Chiaki
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • OH Hakumei
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • SATO Hiroshi
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • CHO Ryuko
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • ISHII Akihiro
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • IKEGAMI Tomoyasu
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • KOGURE Katsuhiro
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • FUKAZAWA Motoharu
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • YOKOTA Akira
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • KAWANO Eiichiro
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • HASHIMOTO Shinichiro
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • MONZAWA Kouji
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • NISHIMURA Miki
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • MATSUURA Yasuhiro
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • HIRUMA Kiyoshi
    Division of Blood Transfusion, Chiba University Hospital
  • NAKAMURA Hirotoshi
    Second Department of Internal Medicine, Chiba University, School of Medicine
  • ASAI Takayoshi
    Division of Blood Transfusion, Chiba University Hospital

Bibliographic Information

Other Title
  • 同種骨髄移植後遅発性出血性膀胱炎に対するprostaglandin E<sub>1</sub>膀胱内注入療法
  • 同種骨髄移植後遅発性出血性膀胱炎に対するprostaglandin E1膀胱内注入療法
  • ドウシュ コツズイ イショクゴ チハツセイ シュッケツセイ ボウコウエン ニ

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Description

Between July, 1990 and March, 1994, 31 patients with hematological malignancies or severe aplastic anemia underwent allogeneic bone marrow transplantation (BMT) at the Second Department of Internal medicine, Chiba University Hospital. Among the 29 evaluable patients who survived over 100 days after transplant, 11 patients (37.9%) developed late-onset hemorrhagic cystitis with a median time of onset of 57 days (range 11-205) from BMT. Adenovirus type 11 was isolated from the urine of 4 patients. Five patients recovered with fluid hydration and forced diuresis, while 6 patients had persistant gross hematuria with clot formation, 5 of whom also developed hydronephrosis. Seven-day courses of 500μg prostaglandin E1 (PGE1) bladder instillations was initiated to control hematuria in these 6 patients. Complete resolution of gross hematuria was achieved in 4, and partial response with decreased clot formation and partial clearing of the urine was observed after 4 of 9 courses of the treatment. Although all patients experienced bladder spasm or lower abdominal pain during the PGE1 instillations, these symptoms were manageable with sedative drugs and morphine. No systemic side effect was apparent. PGE1 bladder instillations is a safe and useful treatment for severe, life-threatening late-onset hemorrhagic cystitis after allogeneic BMT.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 36 (8), 728-734, 1995

    The Japanese Society of Hematology

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