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- GODA Haruyuki
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- ABE Yasunobu
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- YUFU Yuji
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- MUTA Koichiro
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- KATSUNO Makoto
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- GOTO Tatsuro
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- SADAMURA Shingo
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- NISHIMURA Junji
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- NAWATA Hajime
- Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
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- HIRATA Jouji
- Department of Clinical Laboratory, Faculty of Medicine, Kyushu University
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- AKIYOSHI Tomi
- First Department of Internal Medicine, Faculty of Medicine, Fukuoka University
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- KIMURA Nobuhiro
- First Department of Internal Medicine, Faculty of Medicine, Fukuoka University
Bibliographic Information
- Other Title
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- リンパ節と骨髄にて異なった形質を示したＣＤ７陽性幹細胞性白血病の１例
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Abstract
A 27-year-old male with systemic lymphadenopathy was diagnosed as lymphoblastic-type lymphoma by inguinal lymph node biopsy in September, 1990. Bone marrow at the initial diagnosis contained 55.4% lymphoblasts with a phenotype of peroxidase (-), CD7 (+), CD4 (-), CD8 (-). Lymphadenopathy and lymphoblasts in bone marrow disappeared after MACOP-B therapy. In December, 1990, however, the patient again noticed swelling of cervical lymph nodes. At this time, the bone marrow contained 36.4% myeloblasts with a peroxidase (+), CD7 (+), CD13 (+), CD33 (+) phenotype. Cytogenetic and genetic study revealed that the lymphoblasts at the initial diagnosis and the myeloblasts at relapse shared an common abnormal karyotype, 11p-, and the same rearranged band of T-cell receptor δ, γ, β genes, suggesting that these two blasts originated from the same clone. The blasts obtained from the cervical lymph node at relapse were still negative for peroxidase, in contrast to the blasts from bone marrow. These findings suggest that this leukemia originated from a stem cell and differentiated along multilineage pathways.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 33 (8), 1046-1051, 1992
The Japanese Society of Hematology