移植前処置にTBIとTLIを併用し,非血縁者間骨髄移植を行った再生不良性貧血例

書誌事項

タイトル別名
  • Unrelated Match Bone Marrow Transplantation for Severe Aplastic Anemia.

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説明

The results of unrelated bone marrow transplantaion (BMT) is poor because of the rejection of bone marrow graft and graft versus host disease (GVHD). However, the rate of rejection has been reported to be decreased by intensive immuno-suppressive preconditioning regimens combined with total body irradiation (TBI). We report a case of an 18-year-old male with severe aplastic anemia who received a matched BMT from an unrelated donor. The pre-conditioning regimen included cyclophosphamide (50mg/kg) for 4 days, total lymphoid irradiation (TLI: 6Gy) and TBI (5Gy). GVHD (grade 1), hemorrhage cystitis and varicella occured afte BMT but were cured. His performance status is now 100% on the Karnofsky score at 10 months after BMT.

収録刊行物

  • 臨床血液

    臨床血液 34 (12), 1584-1586, 1993

    一般社団法人 日本血液学会

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