Generalized erythema triggered by a rapid decrease of basophils in chronic myeloid leukemia treated with imatinib

DOI Web Site 5 References
  • SUGITO Motoko
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • TSUKADA Junichi
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • HIGASHI Takehiro
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • OHTA Takanori
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • MATSUURA Ai
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • KUBOTA Ayumu
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • MIZOBE Takamitsu
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • MOURI Fumihiko
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • MORIMOTO Hiroaki
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine
  • TANAKA Yoshiya
    First Department Internal Medicine, University of Occupational and Environmental Health, School of Medicine

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Other Title
  • メシル酸イマチニブによる急激な好塩基球減少を契機に全身性紅斑を呈した慢性骨髄性白血病
  • メシルサン イマチニブ ニ ヨル キュウゲキ ナ コウエンキキュウ ゲンショウ オ ケイキ ニ ゼンシンセイコウ ハン オ テイシタ マンセイ コツズイセイ ハッケツビョウ

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Abstract

A 57-year-old woman with chronic myeloid leukemia showing severe basophilia (WBC 17.1×109/L, basophils 23%) was treated with 400mg imatinib in June 2003. A high basophil count (WBC 10.6×109/L, basophils 31%) was still observed after 1 week of therapy. After 9 days of therapy, she developed generalized pruritic skin erythema, chills and high fever. After terminating imatinib treatment, prednisolone therapy was initiated. The rash quickly disappeared. Four days after withdrawal of imatinib, leukocyte count was 13.0×109/L with 3% of basophils, suggesting the possibility that rapid decrease in basophils following imatinib therapy may induce severe cutaneous reactions.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 46 (11), 1226-1228, 2005

    The Japanese Society of Hematology

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