Low-Dose Cytosine Arabinoside (Ara-C) Continuous Infusion Regimen for Atypical Nonlymphocytic Leukemia

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  • TAGAWA Masuko
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • TOMONAGA Masao
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • SHIBATA Junji
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • NISHINO Kenji
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • NONAKA Hiroaki
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • IKEDA Shuichi
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • SUZUYAMA Junji
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • AMENOMORI Tatuhiko
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • MATUO Tatuki
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • KURIYAMA Kazutaka
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • YOSHIDA Yoshiharu
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • SADAMORI Naoki
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine
  • ICHIMARU Michito
    Department of Hematology, Atomic Disease Institute, Nagasaki University School of Medicine

Bibliographic Information

Other Title
  • 非定型白血病に対するCytosine Arabinoside (Ara-C)少量持続注射療法
  • 非定型白血病に対するCytosine arabinoside(Ara-C)少量持続注射療法--染色体所見,コロニー形成およびAra-C血漿濃度からの寛解機序についての解析
  • ヒ テイケイ ハッケツビョウ ニ タイスル Cytosine arabinos
  • —染色体所見，コロニー形成能およびAra-C血漿濃度からの寛解機序についての解析—
  • —Clinical Study on Remission Mechanism by Serial Chromosomal Findings, Colony Formation and Plasma Ara-C Concentration—

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Description

In a series of 6 patients (4 hypoplastic leukemia, 1 acute leukemia from RAEB and 1 erythroleukemia) 7 courses of low dose Ara-C (10∼12 mg/day) regimen were performed for 11∼31 days. Response was noted in 5 patients (6 courses), and complete remission (CR) obtained in 3 patients (4 courses) and partial remission in 2 patients (2 courses).<br>In CR cases a definite cytoreduction phase was observed in bone marrow before normal hematopoiesis recurred. In Case 1 and Case 2 which have 8 trisomy clone (78% and 40%, respectively) before therapy, the bone marrow of CR showed only normal karyotypes in all metaphases examined.<br>Cytogenetic study on single granulocytic colonies and erythroid bursts also revealed only normal karyotypes in Case 1. These findings indicated clonal alternation from leukemic to normal. In all response cases, a few normal granulocyte/macrophage colonies and/or erythroid bursts were observed before therapy and recoverd sufficiently in numbers after therapy.<br>Plasma Ara-C concentration estimated in 6 cases by radioimmunoassay was between 3.53 to 7.38 ng/ml (15 nM∼30nM). According to Harries et al. this level of Ara-C concentration can exert inhibitory activity on DNA sythesis by leukemic myeloblasts to a certain extent.<br>These observations favor a view that low dose Ara-C regimen can induce remission by cytoreduction rather than differentiation-induction.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 25 (10), 1606-1617, 1984

    The Japanese Society of Hematology

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