Superior mesenteric and portal vein thrombosis in a polycythemia vera patient with <i>JAK2</i> mutation

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  • ARAKI Naoko
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TAKIMOTO Rishu
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • CHIBA Hiroki
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • ARAKI Hironobu
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • SATO Tsutomu
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • IYAMA Satoshi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • HIRAKAWA Masahiro
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • ONO Kaoru
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KAWANO Yutaka
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • TAKADA Koichi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • MIYANISHI Koji
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KOBUNE Masayoshi
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • MATSUNAGA Takuya
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • KATO Junji
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine
  • NAKAMURA Tokiko
    Sapporo Junkanki Hospital
  • NIITSU Yoshiro
    Fourth Department of Internal Medicine, Sapporo Medical University School of Medicine

Bibliographic Information

Other Title
  • 上腸間膜静脈・門脈血栓症を発症した<i>JAK2</i>変異を伴った真性多血症
  • 症例報告 上腸間膜静脈・門脈血栓症を発症したJAK2変異を伴った真性多血症
  • ショウレイ ホウコク ジョウチョウカンマク ジョウミャク モンミャク ケッセンショウ オ ハッショウシタ JAK2 ヘンイ オ トモナッタ シンセイ タケツショウ

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Abstract

A 47-year-old woman was admitted to our hospital in December 1994 with polycythemia. The patient's red blood cell volume was 33 ml/kg and bone marrow cytology was able to rule out other myeloproliferative diseases such as chronic myelogenous leukemia, essential thrombocytosis and myelofibrosis. The patient was diagnosed as having polycythemia vera. She had undergone only phlebotomy until 1999 when the thrombocytosis appeared, subsequent to which she was treated with oral hydroxyurea. However, in March 2006, she developed upper abdominal pain and was admitted to our hospital on March 14th, 2006. Computed tomography scan revealed thromboses in the portal and superior mesenteric veins. Anticoagulation therapy delivered intravenously via the superior mesenteric vein dramatically improved her symptoms and liver function. She is currently on anticoagulation therapy in our outpatient clinic.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 48 (7), 554-558, 2007

    The Japanese Society of Hematology

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