低形成型白血病の治療に関する検討　　ＢＨ‐ＡＣ少量療法の臨床効果を中心に

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タイトル別名
  • Treatment of hypoplastic leukemia - Clinical effects of low-dose N-behenoyl-.BETA.-D-arabinofuranosylcytosine (BH-AC) therapy.
  • 低形成型白血病の治療に関する検討--BH-AC少量療法の臨床効果を中心に
  • テイ ケイ セイケイ ハッケツビョウ ノ チリョウ ニ カンスル ケントウ B
  • —Clinical Effects of Low-Dose <sup>4</sup>N-Behenoyl-ß-D-Arabinofuranosylcytosine (BH-AC) Therapy—
  • —BH-AC少量療法の臨床効果を中心に—

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抄録

In this paper the therapeutic effects on 51 patients with hypoplastic leukemia were analyzed in order to establish the optimal clinical management of hypoplastic leukemia. Among 44 patients, hospitalized before 1984, 27 patients were treated with blood transfusion and/or single antileukemic agent, and 17 patients treated with combination chemotherapeutic regimens. As results, only 8, of which 7 patients were received combination chemotherapy, obtained CR and ages of responders were all below 65 years old. On the other hand, among 7 patients treated with low dose behenoyl cytosine arabinoside (LD-BHAC) therapy, applied since 1984, 3 patients obtained CR and 2 patients obtained PR. Responders were aged over 65 years old. Although hematologic toxicities were found during LD-BHAC therapy, they were all controllable. As conclusion, LD-BHAC therapy is thought to be a promising remission induction chemotherapy for aged patients with hypoplastic leukemia.

収録刊行物

  • 臨床血液

    臨床血液 28 (4), 534-540, 1987

    一般社団法人 日本血液学会

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