書誌事項
- タイトル別名
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- Paralytic ileus during treatment of acute promyelocytic leukemia with all-<i>trans</i> retinoic acid
- ATRA トウヨ チュウ ニ マヒセイ イレウス オ キタシタ キュウセイ ゼン コツズイキュウセイ ハッケツビョウ
- 公開日
- 2000
- 資源種別
- journal article
- DOI
-
- 10.11406/rinketsu.41.687
- 公開者
- 一般社団法人 日本血液学会
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説明
A 54-year-old man was referred to our hospital because of petechiae and pancytopenia. Bone marrow aspiration showed a normocellular marrow with 92.4% promyelocytes. PML/RARα mRNA was detected by reverse transcription polymerase chain reaction. On the basis of the above data, a diagnosis of acute promyelocytic leukemia (APL) was made, and treatment with all-trans retinoic acid (ATRA) at a dose of 60 mg/day was begun. Fourteen days after the start of treatment, the patient developed paralytic ileus, accompanied by hyperleukocytosis, high fever, renal dysfunction and elevation of the serum FDP level. There was no evidence of infection. At this time, retinoic acid syndrome was suspected, and therefore steroid pulse therapy was started, which led to an improvement of the symptoms within four days. This case suggests that ATRA may have an adverse effect on the small intestine, causing paralytic ileus.
収録刊行物
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- 臨床血液
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臨床血液 41 (8), 687-689, 2000
一般社団法人 日本血液学会
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詳細情報 詳細情報について
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- CRID
- 1390282680007648256
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- NII論文ID
- 10008038166
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- NII書誌ID
- AN00252940
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- COI
- 1:STN:280:DC%2BD3cvmslKitw%3D%3D
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- ISSN
- 18820824
- 04851439
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- NDL書誌ID
- 6295828
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- PubMed
- 11020999
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- 本文言語コード
- ja
-
- 資料種別
- journal article
-
- データソース種別
-
- JaLC
- NDLサーチ
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可
