Disseminated Intravascular Coagulation in a Case of Adult Onset Still's Disease

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  • SANADA Isao
    Institute for Clinical Research, Kumamoto National Hospital Internal medicine, Kumamoto National Hospital
  • KAWANO Fumio
    Institute for Clinical Research, Kumamoto National Hospital Internal medicine, Kumamoto National Hospital
  • TSUKAMOTO Atsuko
    Internal medicine, Kumamoto National Hospital
  • KIYOKAWA Tetsuyuki
    Internal medicine, Kumamoto National Hospital
  • SHIDO Tadahiro
    Internal medicine, Kumamoto National Hospital
  • KOGA Shin
    Laboratory medicine, Miyazaki Medical College

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Other Title
  • DICを併発した高齢者の成人発症Still病

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Description

We report a 82-year-old woman with adult onset Still's disease (AOSD), who presented with high fever, skin rash, swollen axillary lymph nodes, accelerated erythrocyte sedimentation rate, leukocytosis, abnormal liver function tests, hypoalbuminemia, negative antinuclear antibody and rheumatoid factor, and lack of renal involvement. Disseminated intravascular coagulation (DIC) was also diagnosed on admission. An antipyretic relieved high fever and DIC soon improved. Three years later, AOSD relapsed accompanied by hypercoagulation and hyperfibrinolysis. The patient developed subdural hematoma and DIC due to a brain contusion. High titers of serum soluble adhesion molecules and soluble thrombomodulin were noted on the first episode of DIC. These findings indicated that endothelial cells were damaged in AOSD complicated by DIC.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 38 (11), 1194-1198, 1997

    The Japanese Society of Hematology

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