Characteristic Clinical Features of Adult T-Cell Leukemia (ATL) in Sado Island

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  • AOYAGI Yoshitaka
    The First Department of Internal Medicine, Niigata University School of Medicine
  • TAKAHASHI Masuhiro
    The First Department of Internal Medicine, Niigata University School of Medicine
  • AOKI Sadao
    The First Department of Internal Medicine, Niigata University School of Medicine
  • SHINADA Shoji
    The First Department of Internal Medicine, Niigata University School of Medicine
  • HATTORI Akira
    The First Department of Internal Medicine, Niigata University School of Medicine
  • SHIBATA Akira
    The First Department of Internal Medicine, Niigata University School of Medicine
  • NEMOTO Keiichi
    The Second Department of Pathology, Niigata University School of Medicine
  • TSUKADA Tsuneyasu
    Hematology Division, Niigata Shimin Hospital
  • MIYAKOSHI Hideo
    Research Division, Shinrakuen Hospital
  • KOIDE Hiroko
    Research Division, Shinrakuen Hospital
  • AOKI Tadao
    Research Division, Shinrakuen Hospital

Bibliographic Information

Other Title
  • 佐渡地方に見られる成人T細胞白血病(ATL)の特異的臨床像
  • サド チホウ ニ ミラレル セイジン Tサイボウ ハッケツビョウ ATL ノ

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Description

Eight patients with adult T-cell leukemia (ATL) were treated in our Department for last 7 years. Six patients out of eight were the native residents of Sado Island who showed characteristic clinical features, e.g. longer survival than that of the patients in other endemic areas and a variety of skin lesions. In view of the fact that the total population of this island is about 80,000, the incidence of ATL patients in this island is thought to be high.<br>All patients tested possessed both ATL-associated retrovirus (ATLV)-antigens in peripheral blood lymphocytes after short-time culture and natural antibody in serum against ATLV. The findings agreed with the results of virological analysis for patients with ATL in other areas of Japan. From the point of view of the similarity of ATLV, the route and clustering of ATLV were discussed. Furthermore, it was speculated that the characteristics of clinical features of the patients in Sado Island may due to mutation of ATLV and/or the immunological change of these residents against ATLV.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 24 (10), 1321-1330, 1983

    The Japanese Society of Hematology

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