成人Ｔ細胞白血病における臨床病型とＥｐｓｔｅｉｎ‐Ｂａｒｒ　Ｖｉｒｕｓ関連抗体との関係

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  • Relationship between the clinical subtype and Epstein-Barr virus specific antibodies in patients with adult T-cell leukemia.
  • 成人T細胞白血病における臨床病型とEpstein-Barr virus関連抗体との関係
  • セイジン Tサイボウ ハッケツビョウ ニ オケル リンショウ ビョウケイ ト

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In order to clarify the immune response in adult T cell leukemiea (ATL), Epstin-Barr virus (EBV)-specific antibody titers in sera from 35 patients with ATL and 128 healthy controls were measured by an immunofluorecence method. EBV is an infectious agent ubiqitous throughout the world and is koown to be latent lifelong. When the immune competence in host is depressed, EBV may be reactivated, resulting in a change of EBV-specific antibody titers.<br>Our findings showed that the mean titers of EBV capsid antigen (VCA)-IgG antibody and the positive rate of early antigen (EA)-IgG antibody in sera of patients with smoldering type ATL were higher than in sera of healthy controls. And these antibody titers increased with the stage of ATL. However, no differences were seen in antibody titers to EBV-associated nuclear antigen (EBNA) between the ATL patients and the controls.<br>These results suggest that there may be an abnormality in the immune competence in persons infected with human T cell lymphotropic virus type-1 (HTLV-1).

収録刊行物

  • 臨床血液

    臨床血液 28 (8), 1403-1408, 1987

    一般社団法人 日本血液学会

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