Clinical Studies on Superoxide Production of Neutrophils in Patients with Acute Leukemia
-
- KOUI Fumikazu
- Department of Medicine, Okayama University Medical School
-
- OHMOTO Eijiro
- Department of Medicine, Okayama University Medical School
-
- ODA Yasuhiro
- Department of Medicine, Okayama University Medical School
-
- FUJIMOTO Shuitsu
- Department of Medicine, Okayama University Medical School
-
- ENDO Hiroshi
- Department of Medicine, Okayama University Medical School
-
- UCHIDA Kozaburo
- Department of Medicine, Okayama University Medical School
-
- TAKAOKA Kazuko
- Department of Medicine, Okayama University Medical School
-
- HARA Masamichi
- Department of Medicine, Okayama University Medical School
-
- WATANABE Seiichiro
- Department of Medicine, Okayama University Medical School
-
- LAI Minyu
- Department of Medicine, Okayama University Medical School
-
- TAKAHASHI Isao
- Department of Medicine, Okayama University Medical School
-
- KITAJIMA Koichi
- Department of Medicine, Okayama University Medical School
-
- KIMURA Ikuro
- Department of Medicine, Okayama University Medical School
-
- SANADA Hiroshi
- Department of Laboratory, Okayama University Medical School
-
- YORIMITSU Seiichi
- Department of Medicine, Ehime Kenritsu Chuo Hospital
Bibliographic Information
- Other Title
-
- 急性白血病における好中球Superoxide産生能の検討
- キュウセイ ハッケツビョウ ニ オケル コウチュウキュウ superoxide
Search this article
Abstract
Superoxide of neutrophils is one of the acitive oxygens related to intracellular bactericidal activities. In this study, superoxide production of neutrophils in both normal subjects and patients with acute leukemia was examined in order to evaluate the cause of the high susecptibility to infection. The results were as follows.<br>1. Superoxide production of neutrophils was significantly lower in the older subjects (70-89 y.o.) than in the younger ones (20-69 y.o.). No significant difference was shown between males and females.<br>2. Before antileukemic chemotherapy superoxide production was 4.09±1.43 nmol/min/106 PMNs in patients with acute leukemia (normal subjects; 6.45±1.33 nmol/min/106 PMNs). During induction chemotherapy it decreased to a level of 3.56±1.18 nmol/min/106 PMNs and it increased up to normal or slightly higer levels in a complete remission. The changes in superoxide production did not relate to the types of acute leukemia.<br>3. An inverse correlation between superoxide production of neutrophils and the total number of leukemic cells in the bone marrow was recognized.<br>The results may suggest that the decrease in superoxide production of neutrophils contribute one of the causes of high susceptibility to infection in the elderly men and patints with acute leukemia.
Journal
-
- Rinsho Ketsueki
-
Rinsho Ketsueki 24 (1), 1-8, 1983
The Japanese Society of Hematology
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282680008159488
-
- NII Article ID
- 40003771547
- 130004498496
-
- NII Book ID
- AN00252940
-
- COI
- 1:STN:280:BiyC1cbmtlI%3D
-
- ISSN
- 18820824
- 04851439
-
- NDL BIB ID
- 2622801
-
- PubMed
- 6302347
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- NDL
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed