Significance of soluble interleukin-2 receptor α chain in the management of patients with malignant lymphoma: a multi-center study

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  • 悪性リンパ腫診療における可溶性インターロイキン2受容体α鎖の重要性—多施設共同研究—
  • 臨床研究 悪性リンパ腫診療における可溶性インターロイキン2受容体α鎖の重要性--多施設共同研究
  • リンショウ ケンキュウ アクセイ リンパ シュ シンリョウ ニ オケル カヨウセイ インターロイキン 2 ジュヨウタイ アルファ サ ノ ジュウヨウセイ タシセツ キョウドウ ケンキュウ

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Abstract

A multi-center series of 117 patients with malignant lymphoma were analyzed to evaluate the clinical significance of soluble interleukin-2 receptor α chain (sIL-2Rα). The initial levels of sIL-2Rα ranged from 277 U/ml to 22,800 U/ml with a mean level of 3,451±4,268 U/ml and a median level of 1,600 U/ml. The sIL-2Rα levels of the diffuse lymphoma/intermediate-grade subtypes defined by the LSG classification/Working Formulation were higher than those of the follicular lymphoma/low-grade subtypes. There was a tendency for B-cell lymphomas to show higher sIL-2Rα levels than T-cell lymphomas. The sIL-2Rα level was correlated with the Ann Arbor clinical stage (I, II versus III, IV), presence or absence of B symptoms, and performance status (0, 1 versus 2, 3, 4) of the patients. The sIL-2Rα levels were in good accordance with the four risk groups defined by the International Prognostic Indices. Of 21 patients whose tumor burden was serially measured, the coefficients of correlation between sIL-2Rα and tumor mass were >0.6 in 18 cases. Sixty-two patients achieved complete remission (CR) during the study; the initial and minimum sIL-2Rα levels were lower than those of the non-CR patients. This study confirmed that sIL-2Rα is a convenient and useful marker in the management of malignant lymphoma.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 43 (3), 170-175, 2002

    The Japanese Society of Hematology

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