同種骨髄移植後，頻回輸血による二次性ヘモクロマトーシスに対しエリスロポエチン併用瀉血療法が著効を奏した骨髄異形成症候群

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タイトル別名
  • Successful treatment using iron depletion phlebotomy combined with recombinant erythropoietin after allogeneic bone marrow transplantation for myelodysplastic syndrome complicated by secondary hemochromatosis
  • ドウシュ コツズイ イショク ゴ ヒンカイ ユケツ ニ ヨル 2ジセイ ヘモクロマトーシス ニ タイシ エリスロポエチン ヘイヨウシャケツ リョウホウ ガ チョコウ オ ソウ シタ コツズイイケイセイ ショウコウグン

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説明

A 33 year-old female patient presented with apparent skin pigmentation, sustained liver dysfunction and impaired glucose tolerance. She had received blood transfusions totalling more than 40,000 ml for myelodysplastic syndrome and an allogeneic bone marrow transplant from her HLA-matched sister at the age of 31. Ferrokinetic data showed a significant iron overload. Magnetic resonance imaging suggested excessive iron deposition in the liver. The patient was diagnosed as having secondary hemochromatosis. She was given subcutaneous injections of 6,000 units of recombinant human erythropoietin initially twice a week and then weekly, and phlebotomies were performed to maintain her hemoglobin level above 10 g/dl. Three years later, the total volume of phlebotomized blood reached 24,000 ml, and her ferrokinetic data, serum transaminase levels, glucose tolerance and skin color were significantly improved.

収録刊行物

  • 臨床血液

    臨床血液 42 (7), 571-574, 2001

    一般社団法人 日本血液学会

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