Antiapoptotic functions of the retrovirally transferred API2-MALT1 gene

DOI Web Site 17 References
  • MAYAMA Ko
    Division of Molecular Medicine, Aichi Cancer Center Research Institute First Department of Internal Medicine, Hirosaki University School of Medicine
  • TSUZUKI Shinobu
    Division of Molecular Medicine, Aichi Cancer Center Research Institute
  • SETO Masao
    Division of Molecular Medicine, Aichi Cancer Center Research Institute

Bibliographic Information

Other Title
  • 粘膜関連リンパ組織(MALT)リンパ腫転座関連遺伝子API2-MALT1のアポトーシス抑制効果
  • 臨床研究 粘膜関連リンパ組織(MALT)リンパ腺転座関連遺伝子API2-MALT1のアポトーシス抑制効果
  • リンショウ ケンキュウ ネンマク カンレン リンパ ソシキ MALT リンパセンテンザカンレン イデンシ API2 MALT1 ノ アポトーシス ヨクセイ コウカ

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Description

t(11;18)(q21;q21) is a specific chromosomal aberration in mucosa-associated lymphoid tissue (MALT) lymphoma, and produces chimeric transcript Apoptosis Inhibitor 2 (API2)-MALT1. Although it is known that API2 has an antiapoptotic effect, it is still unclear whether this also applies to API2-MALT1. To investigate its effects against various apoptotic stimuli, API2-MALT1 was expressed by means of retroviral infection on the epithelial cell line HeLa and the murine Pro-B cell line Ba/F3. On both these cell lines, API2-MALT1 was found to cause a significant reduction in UV-induced apoptosis. The apoptosis induced by doxorubicin was also inhibited by API2-MALT1, but not that induced by IL-3 withdrawal from Ba/F3. These findings suggest that API2-MALT1 has an antiapoptotic effect on both epithelial and lymphoid cells and that this effect depends on the apoptotic stimulus.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 46 (7), 479-485, 2005

    The Japanese Society of Hematology

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