Leukemic Cell Kill Kinetics in Bone Marrow

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  • 急性白血病初回寛解導入における骨髄内白血病細胞減少動態の解析
  • キュウセイ ハッケツビョウ ショカイ カンカイ ドウニュウ ニ オケル コツズ

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Abstract

On the basis of countersigmoid curve of tumor regression in experimental model, the equation for leukemic cell kill kinetics during the first induction chemotherapy (logZ=K1t4+K2t3+K3t2+K4Z: leukemic cell number at time t t: time in day K: constant), was composed by computing absolute numbers of leukemic cells per cumm at sternum in 36 previously untreated acute nonlymphocytic leukemia patients. The leukemic cell kill curve was composed from two different phases, phase I and II; phase I corresponding to period from the initiation of decrease of leukemic cells (Point A) to the time of maximum velocity of decrease (Point B), and phase II from Point B to the time of cessation of decrease of leukemic cells (Point C). Determinating coefficients for computed curves were 0.90±0.20 in patients with complete remission (CR) and 0.78±0.36 in patients without CR, respectively.<br>The parameters for leukemic cell kill curve, i.e, the durations of phase I and II, the accelerations of decrease at Phase I and II, the maximum velocity of decrease, the duration from Point A to C (the duration of phase I plus II) and the residual volume of leukemic cells (leukemic cell number at Point C) were compared among two groups; patients with or without CR. Patients with CR showed the longer duration of phase I and II, the lower acceleration of decrease at Phase II, smaller volume of residual leukemic cells, and the relatively high maximum velocity of decrease, resulting into the cell kill curve showing a relatively sharp at phase I and a gentle slope at phase II. The new equation for leukemic cell kill kinetics in acute leukemia marrow is thought to be available not only for the early evaluation of therapeutic effect but also for the modification of treatment schedule during the induction chemotherapy.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 27 (9), 1590-1595, 1986

    The Japanese Society of Hematology

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