Idiopathic hyperammonemia following allogeneic bone marrow transplantation for refractory lymphoma.

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  • WATANABE Reiko
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University
  • OKAMOTO Shinichiro
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University
  • ASAHI Atsuko
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University
  • MORI Takehiko
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University
  • TAKAYAMA Nobuyuki
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University
  • IKEDA Yasuo
    Division of Hematology, Department of Internal Medicine, School of Medicine, Keio University

Bibliographic Information

Other Title
  • 非血縁者間骨髄移植後の特発性高アンモニア血症
  • ヒケツエンシャ カン コツズイ イショク ゴ ノ トクハツセイ コウアンモニア ケッショウ

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Description

Idiopathic hyperammonemia (IHA) is a rare but serious complication of stem cell transplantation. We report a patient with immunoblastic lymphoadenopathy-like T-cell lymphoma who developed IHA 10 days after allogeneic bone marrow transplantation from an HLA-matched unrelated donor. Despite intensive supportive care, the patient died due to this metabolic disorder two days later. Being mindful of the possibility of IHA in patients who develop confusion and respiratory alkalosis soon after stem cell transplantation would allow earlier treatment and might improve the chance of survival.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 41 (12), 1285-1288, 2000

    The Japanese Society of Hematology

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