Primary diffuse large B-cell lymphoma of the bone marrow complicated with autoimmune hemolytic anemia and erythroid hypoplasia

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  • 赤芽球低形成を伴う自己免疫性溶血性貧血を認めた骨髄原発びまん性大細胞型B細胞リンパ腫
  • 症例報告 赤芽球低形成を伴う自己免疫性溶血性貧血を認めた骨髄原発びまん性大細胞型B細胞リンパ腫
  • ショウレイ ホウコク セキガキュウ テイケイセイ オ トモナウ ジコ メンエキセイ ヨウケツセイ ヒンケツ オ ミトメタ コツズイ ゲンパツ ビマンセイ ダイサイボウガタ Bサイボウ リンパシュ

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Abstract

A 75-year-old woman was admitted for general fatigue. Diagnostic investigations showed no lymphadenopathy or hepatosplenomegaly. Laboratory examinations revealed severe anemia and an undetectable level of haptoglobin in the peripheral blood. A direct Coombs test was positive. Bone marrow examination showed abnormal, large, CD20-positive lymphocytes and erythroid hypoplasia. Accordingly, a diagnosis of primary diffuse large B-cell lymphoma (DLBCL) of the bone marrow with autoimmune hemolytic anemia (AIHA) and erythroid hypoplasia was made. The patient was treated with prednisolone and 3 courses of rituximab, followed by 6 courses of R-CHOP. AIHA and erythroid hypoplasia subsided after prednisolone and 3 courses of rituximab. Treatment with 6 courses of R-CHOP resulted in complete remission. Isolated bone marrow disease as a presenting feature of DLBCL is very rare. Although malignant lymphomas are often associated with immunologic disorders, this is the first report of diffuse large B-cell lymphoma with isolated bone marrow disease and simultaneous autoimmune hemolytic anemia and erythroid hypoplasia. This case provides valuable information concerning the pathophysiology of an immunologic anomaly with malignant lymphoma.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 48 (7), 571-575, 2007

    The Japanese Society of Hematology

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