Detection of Suppressor Lymphocytes to Hematopoietic Stem Cells in Patients with Aplastic Anemia<br>Pre-treatment of the Bone Marrow Cells with Anti-lymphocyte Globulin

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  • 再生不良性貧血における造血幹細胞抑制リンパ球の検出—抗リンパ球グロブリンによる骨髄細胞処理法の検討—
  • 再生不良性貧血における造血幹細胞抑制リンパ球の検出--抗リンパ球グロブリンによる骨髄細胞処理法の検討
  • サイセイ フリョウセイ ヒンケツ ニ オケル ゾウケツ カンサイボウ ヨクセイ

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Description

In order to detect suppressor lymphocytes to hematopoietic stem cells, CFU-E colony growth was compared before and after pre-treatment of bone marrow cells with anti-lymphocyte globulin (ALG) and complement in 17 patients with aplastic anemia. Peripheral blood T lymphocytes which suppressed allogeneic CFU-E colony growth were found in 7 cases. In 3 out of these 7 cases, CFU-E colony growth from patients' own marrow cells was enhanced significantly by pre-treatment with ALG and complement, but in the remaining 4 cases no significant enhancement was found. ALG therapy was given 3 cases in whom pre-treatment of bone marrow cells with ALG and complement in vitro enhanced CFU-E colony growth. This therapy was effective in only 2 cases. It is suggested that the results of in vitro tests can not predict the effectiveness of ALG therapy in vivo.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 26 (3), 357-361, 1985

    The Japanese Society of Hematology

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