ITPにおける血小板抗体の解析—血小板表面IgGと血清中血小板結合性IgGの比較検討

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タイトル別名
  • Detection of Platelet Antibody in Idiopathic Thrombocytopenic Purpura: Comparison between Platelet-Associated IgG and Platelet-Binding IgG in Serum
  • ITPにおける血小板抗体の解析-血小板表面IgGと血清中血小板結合性IgGの比較検討
  • ITP ニ オケル ケッショウバン コウタイ ノ カイセキ ケッショウバン ヒ

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We reported previously a competitive solid-phase enzyme immunoassay to measure platelet-associated IgG (PAIgG). The results indicated that 93% of patients with idiopathic thrombocytopenic purpura (ITP) had elevated PAIgG values and there was a good inverse correlation between PAIgG values and platelet counts. In this report, using our assay, platelet-binding IgG (PBIgG) in ITP serum was measured. Ten of 20 patients had elevated PBIgG values. There was no correlation between PBIgG values and platelet counts nor correlation between PAIgG values and PBIgG values. It was indicated that PBIgG had differences in the affinity for normal platelet. It is considered that PBIgG is not so important as PAIgG in the destructive mechanism of platelet.

収録刊行物

  • 臨床血液

    臨床血液 23 (1), 40-45, 1982

    一般社団法人 日本血液学会

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