多発性筋炎を伴った自己免疫性溶血性貧血の1例

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タイトル別名
  • A Case of Autoimmune Hemolytic Anemia Complicated by Polymyositis
  • タハツセイ キンエン オ トモナッタ ジコ メンエキセイ ヨウケツセイ ヒンケ

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説明

A 49-year-old man was admitted to Nagoya City University Hospital on July 11, 1978, for a further examination of fever of unknown origin, anemia and muscle weakness. Physical examination revealed marked muscle weakness and atrophy in the proximal muscle of the extremities. On admission, his hemoglobin was 10.9g/dl, reticulocytes 46%, platelelts 45.2×104/mm3, WBC 19,600/mm3 with 84% of neutrophils. His bone marrow smear revealed an erythroid marrow. A shortened 51Cr red cell life span, positive direct Coombs test, elevated reticulocytes, increased serum bilirubin, markedly decreased haptoglobin led to the diagnosis of autoimmune hemolytic anemia (AIHA). A diagnosis of polymyositis was also made from myogenic changes in EMG and muscle biopsy findings. Anemia and muscle weakness were improved, and the levels of LDH, CPK, GOT and ESR were normalized by the administration of prednisolone and azathioprine. To our knowledge, cases of AIHA complicated by polymyositis are very few. This case is of interest from the point of view of understanding the onset of antoimmune disease because of the simultaneously involvement of two organs in one individual.

収録刊行物

  • 臨床血液

    臨床血液 22 (1), 11-15, 1981

    一般社団法人 日本血液学会

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