Paroxysmal Nocturnal Hemoglobinuria: On Its Clinical and Experimental Aspects, and Bibliographical Considerations of the Cases Reported in Japan

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Bibliographic Information

Other Title
  • 発作性夜間血色素尿症
  • 発作性夜間血色素尿症 症例の検討と本邦報告例の文献的考察
  • ホッサセイ ヤカン ケッシキソ ニョウショウ ショウレイ ノ ケントウ ト ホンポウ ホウコクレイ ノ ブンケンテキ コウサツ
  • —症例の検討と本邦報告例の文献的考察—

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Abstract

A case of paroxysmal nocturnal hemoglobinuria (PNH), 39 years old male, was reported. Biochemical analyses on the constituents of lipid and phospholipid of the erythrocyte revealed increase of total lipids and especially of palmitic acid in contrast of decrease of linoleic acid. Although a coarse granular change in the ghoast membrane was observed electron-micrscopically in the patient erythrocyte, the specific structual abnormalities of the erythrocyte stroma in PNH were hardly determined for the moment. Activity of acetylcholinesterase of the erythrocyte was also decreased remarkably. The increase of the hemolysis and hemolytic factors in plasma were discussed according to lieratures, and 54 cases of PNH in Japan including the present case were riviewed.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 9 (3), 436-444, 1968

    The Japanese Society of Hematology

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