Assay of Plasma Heparin and Heparin-Antithrombin III Complex

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  • OGUMA Yutaka
    The First Department of Medicine, Hokkaido University School of Medicine
  • HASEGAWA Hiroshi
    The First Department of Medicine, Hokkaido University School of Medicine
  • NAGATA Hiroshi
    The First Department of Medicine, Hokkaido University School of Medicine
  • KAWAKAMI Yoshikazu
    The First Department of Medicine, Hokkaido University School of Medicine

Bibliographic Information

Other Title
  • 血中ヘパリン濃度とヘパリン・アンチトロンビンIII複合体活性の測定
  • 血中ヘパリン濃度とヘパリン・アンチトロンビン3複合体活性の測定--健常人,各種血栓性疾患患者による検討
  • ケッチュウ ヘパリン ノウド ト ヘパリン アンチトロンビン3フクゴウタイ カ
  • —健常人，各種血栓性疾患々者による検討—
  • —Studies in Normal Volunteers and Thromboembolic Patients—

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Description

We investigated the relations among heparin (Hp)•antithrombin III (ATIII) complex (HAC), plasma Hp concentration and APTT in 15 nomal volunteers and 12 thromboembolic patients. The activities of HAC and the concentrations of plasma Hp were assayed by Hp monitor test (HMT) and by Testozym S-2222 method (TST), respectively. The ratio of HMT/TST exhibited the relative amounts of HAC in plasma. HMT and TST had equally good correlations to APTT and had a good (p<0.01) correlation to each other in all cases. But in each case, they showed quite different regression lines. HAC synthesis was related not only to the levels of Hp and ATIII but also to many other factors which fluctuated significantly according to the indivisual case. Recovery from the thromboembolic conditions was seen in cases whose levels of TST and HMT revealed more than 0.4 and 0.1U/ml, respectively and it was demonstrated that subcutaneous administration of Hp with the dose of 250U/kg at every 12 hours was quite useful to obtain these therapeutic levels.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 27 (5), 723-729, 1986

    The Japanese Society of Hematology

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