A Case of Sideroblastic Anemia Associated with Primary Thrombocythemia

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  • SAITO Kenji
    The third department of internal medicine, Dokkyo university school of medicine
  • YAMAZAKI Tatsuya
    The third department of internal medicine, Dokkyo university school of medicine
  • TAKAHASHI Katsunori
    The third department of internal medicine, Dokkyo university school of medicine
  • NAMBA Yasuko
    The third department of internal medicine, Dokkyo university school of medicine
  • HAMAGUCHI Hiroyuki
    The third department of internal medicine, Dokkyo university school of medicine
  • SAKAMAKI Hisashi
    The third department of internal medicine, Dokkyo university school of medicine
  • HAZAMA Sakae
    The third department of internal medicine, Dokkyo university school of medicine
  • ENOKIHARA Hideo
    The third department of internal medicine, Dokkyo university school of medicine
  • FURUSAWA Shimpei
    The third department of internal medicine, Dokkyo university school of medicine
  • SHISHIDO Hideo
    The third department of internal medicine, Dokkyo university school of medicine

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Other Title
  • 鉄芽球性貧血に血小板血症を併発した1例
  • テツガキュウセイ ヒンケツ ニ ケッショウバン ケッショウ オ ヘイハツシタ

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Abstract

A 67-year-old male was admitted to our hospital because of marked thrombocytosis and leukocytosis. Peripheral blood examination revealed RBC 355×104/cmm, Hb 10.7 g/dl, leukocyte count 15,400/cmm with 62% neutrophils, 9% eosinophils and 5% basophils, and platelet count 139.8×104/cmm. Bone marrow aspirate showed hypercellularity of three myeloid elements with 22% erythroblasts and megakaryocyte count 465/cmm. Ringed sideroblasts were seen in 58% of erythroblasts. Chromosome analysis of the bone marrow cells showed no abnormality. Both the activities of ALA synthetase and neutral protease in erythroblasts were reduced.<br>This patient was thought to have two diseases, acquired sideroblastic anemia and thrombocythemia. As both are supposed to be a myeloid stem cell disorder, it seems to be a matter of choice whether he is diagnosed as primary acquired sideroblastic anemia associated with thrombocytosis or primary thrombocythemia associated with acquired sideroblastic anemia.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 23 (12), 1889-1894, 1982

    The Japanese Society of Hematology

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