バセドウ病と特発性血小板減少性紫斑病の合併した1例

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タイトル別名
  • A Case of Idiopathic Thrombocytopenic Purpura Associated with Basedow's Disease
  • バセドウビョウ ト トクハツセイ ケッショウバン ゲンショウセイ シハンビョウ

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抄録

A 31-year-old female was referred to our hospital on March 19, 1980, because of purpura and hypermenorrhea over one year with no response to prednisolone therapy. Her past history was noncontributory. Physical findings on admission; scattered petechiae were observed on the upper and lower extremities and the neck. She had a diffuse goiter and an exophthalmus, but no hepatosplenomegaly. Laboratory examination revealed a marked thrombocytopenia (10,000/mm3) with normal red cell and leukocyte counts in peripheral blood. Bone marrow aspiration was unremarkable with normal megakaryocyte count (50/mm3). Serum levels of T4 (13.4μg/dl) and T3 (2.17ng/ml) were both elevated and that of TSH (less than 0.3μIU/ml) depressed. TRH test was unresponsive. Serologically, anti-platelet antibody was negative, thyroid test (×802) and microsome test (×1602) were both positive.<br>On the diagnosis of ITP associated with Basedow's disease, combination therapy of prednisolone and methimazole was instituted with a rapid increase of platelet count to normal. When she became euthyroid, prednisolone therapy was tapered off. The platelet count was sustained normal.<br>The mechanism of the co-occurrence of ITP and Basedow's disease was discussed.

収録刊行物

  • 臨床血液

    臨床血液 23 (2), 185-192, 1982

    一般社団法人 日本血液学会

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