An Attempt of S Phase Partial Synchronization by N<sup>4</sup>-Behenoyl-1-β-d-arabinofuranosylcytosine in Treatment of Adult Acute Nonlymphocytic Leukemia

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  • OHTAKE Shigeki
    3rd Department of Internal Medicine, Kanazawa University School of Medicine
  • KOBAYASHI Saburo
    3rd Department of Internal Medicine, Kanazawa University School of Medicine
  • YOSHIDA Takashi
    3rd Department of Internal Medicine, Kanazawa University School of Medicine
  • NAKAMURA Shinobu
    3rd Department of Internal Medicine, Kanazawa University School of Medicine
  • TANIMOTO Kazuo
    School of Paramedicine, Kanazawa University
  • HATTORI Ken-ichi
    3rd Department of Internal Medicine, Kanazawa University School of Medicine

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Other Title
  • 成人急性非リンパ性白血病治療におけるN<sup>4</sup>-Behenoyl-1-β-d-arabinofuranosylcytosineによるS-phase partial synchronizationの試み
  • 成人急性非リンパ性白血病治療におけるN4-Behenoyl-1-β-d-arabinofuranosylcytosineによるS-phase partial synchronizationの試み
  • セイジン キュウセイ ヒ リンパセイ ハッケツビョウ チリョウ ニ オケル N

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Abstract

S phase partial synchronization by N4-behenoyl-1-β-d-arabinofuranosylcytosine (BH-AC) was attempted in 13 adults with acute nonlymphocytic leukemia. The patients whose marrow leukemic blasts were normo- or hypocelluar and showed labeling indices (LI) of 3∼10% as determined by our rapid 3H-TdR autoradiography were selected and administrated BH-AC 100mg/day by 3-hour drip intravenous infusion for 2 or 4 days. LI rose significantly (P<0.01) from 5.3±1.7% to 9.9±3.5% in 2 days treatment group and from 5.0±2.2% to 10.6±6.7% in 4 days treatment group (P<0.05). Slight nausea but not pain of salivary gland and megaloblastic change in marrow were observed during administration of BH-AC. The mechanism of synchronization by BH-AC was considered S phase prolongation by the inhibition of DNA synthesis.<br>Remission induction therapy by DCMP or DBMP at a proper time carefully determined by LI of marrow blasts according to our new protocol gave complete remission rate of 85.7%, i.e., 6 of the 7 firstly treated cases and that of 57.1%, i.e., 4 of the 7 reccurent cases.<br>From our above-mentioned results, S phase partial synchronization by BH-AC by the use of our rapid autoradiography is considered to be a useful tool for treatment of leukemia.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 22 (1), 1-10, 1981

    The Japanese Society of Hematology

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