Pure Red Cell Aplasia Associated with Chloramphenicol Treatment Case report and review of the literature in Japan.

DOI Web Site
  • YAMADA Hideo
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • NAKASHIMA Izumi
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • YASUMA Akiyasu
    Chukyo Hospital, Department of Internal Medicine

Bibliographic Information

Other Title
  • ChloramphenicolによるPure Red Cell Aplasiaの1症例
  • Chloramphenicol ニ ヨル Pure red cell Aplasia ノ 1 ショウレイ

Search this article

Abstract

Pure red cell aplasia was found in a patient (31-year-old man) with infectious hepatitis who was treated with chloramphenicol, 1500 mg daily for supposed infection of biliary tract. Bone marrow aspiration showed almost complete absence of erythroid cells with normal myeloid series and megakaryocytes.<br>There remained 3.6 percent of erythroid cells in bone marrow all of which were vacuolated primitive erythroblasts. There was a rapid and complete recovery after discontinuance of the drug. Ferrokinetics studies were performed before and after his hematological recovery.<br>In a review of the literature in Japan, we found five instances of pure red cell aplasia associated with chloramphenicol therapy. Five patients including our case recovered when the drug was removed.<br>Finally the pathogenetic mechanism for chloramphenicol-induced pure cell aplasia has been discussed on the basis of current literature.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 11 (1), 58-65, 1970

    The Japanese Society of Hematology

Details 詳細情報について

Report a problem

Back to top