小児急性前骨髄球性白血病（ＦＡＢ　Ｍ３）の晩期再発　　小児急性非リンパ性白血病の治療成績からみたＭ３例の特殊性

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タイトル別名
  • Late relapse of acute promyelocytic leukemia(FAB M3) in childhood. Characteristic therapeutic results of M3 compared to other types of non-lymphocytic leukemia.
  • ショウニ キュウセイ ゼン コツズイキュウセイ ハッケツビョウ FAB M3
  • —Characteristic Therapeutic Results of M3 Compared to Other Types of Non-lymphocytic Leukemia—
  • —小児急性非リンパ性白血病の治療成績からみたM3例の特殊性—

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説明

During the past 6 years from 1981 through 1986, a total of 33 new cases of childhood acute non-lymphoblastic leukemia (ANLL) were treated with an intensive multi-drug chemotherapy at the Department of Pediatrics, Kyoto Prefectural University of Medicine and other affiliated pediatric clinics.<br>Excluding 2 cases still receiving early induction therapy, 24 of the remaining 31 cases (78%) attained complete remission (CR); a half of which relapsed or died within 15 months, but another half had, or has been in continuous complete remission (CCR) for over 24 months after beginning of the induction therapy.<br>All of the 5 M3 patients attained CR and had or has been in CCR over 24 months, indicating that M3 cases easily achieve long term CR. On the other hand, 19 of the other 26 ANLL cases attained CR but only 7 cases had or has been in CCR over 24 months. However, late relapse after 24 months occurred in 3 of the 5 M3 cases, compared with 1 in the 7 other ANLL cases.<br>Our results may suggest that protocols for M3 cases should be modified to include more intensified, and long-duration maintenance chemotherapy, in order to prevent late relapse.

収録刊行物

  • 臨床血液

    臨床血液 29 (2), 137-143, 1988

    一般社団法人 日本血液学会

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