Proposals of the Diagnostic Criteria for Refractory Anemias

DOI Web Site PubMed 3 Citations
  • UCHINO Haruto
    The First Division, Department of Internal Medicine, Kyoto University
  • YOSHIDA Yataro
    The First Division, Department of Internal Medicine, Kyoto University
  • YAMAGISHI Morihisa
    The First Division, Department of Internal Medicine, Kyoto University
  • MIYAZAKI Tamotsu
    The Third Department of Internal Medicine, Hokkaido University
  • OMINE Mitsuhiro
    The Third Department of Internal Medicine, Gunma University
  • MAEKAWA Tadashi
    The Third Department of Internal Medicine, Gunma University
  • MIURA Yasusada
    Department of Hematology, Jichi Medical School
  • TAKAKU Fumimaro
    The Third Department of Internal Medicine, University of Tokyo
  • MIZOGUCHI Hideaki
    The First Department of Internal Medicine, Tokyo Women's Medical College
  • URANO Yorifumi
    Department of Pathology, University of Tokyo
  • NOMURA Takeo
    The Third Department of Internal Medicine, Nippon Medical School
  • YAMADA Hideo
    The First Department of Internal Medicine, Nagoya University
  • KURAMOTO Atsushi
    Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University
  • KAMADA Nanao
    Department of Internal Medicine, Research Institute for Nuclear Medicine and Biology, Hiroshima University
  • TOMONAGA Masao
    Department of Internal Medicine, Atomic Disease Institute, Nagasaki University
  • ICHIMARU Michito
    Department of Internal Medicine, Atomic Disease Institute, Nagasaki University
  • SHIBATA Akira
    The Third Department of Internal Medicine, Niigata University

Bibliographic Information

Other Title
  • 不応性貧血の診断基準の提唱
  • フ オウセイ ヒンケツ ノ シンダン キジュン ノ テイショウ

Search this article

Abstract

Although refractory anemias in the broad sense are not a homogenous disease entity, their spectrum of clinical and hematological features have been sufficiently characterized to permit prospective observation. Based on the clinical and hematological data of 265 patients, new diagnostic criteria for the diagnosis of refractory anemias is proposed.<br>The criteria for screening includes<br>1) anemia (including bicytopenia and pancytopenia),<br>2) cellular marrow,<br>3) chronic irreversible course,<br>4) absence of underlying causes or drugs and<br>5) marrow blasts less than 20%.<br>Cases of myloproliferative disorders, aplastic anemia, idiopathic thrombocytopenic purpura or hemolytic anemia be excluded. The criteria for confirmation includes presence of ineffective hemopoiesis and/or dysplastic morphological changes. Refractory anemias in the broad sence are classified into four disease types, primary acquired refractory anemia, primary acquired sideroblastic anemia, refractory anemia with excess of blasts, and refractory cytopenia. Certain morphological features of diagnostic relevance were also described to facilitate the distinction of the disease types.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 27 (1), 36-42, 1986

    The Japanese Society of Hematology

Citations (3)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top