Acute promyelocytic leukemia with a history of RAEB in transformation and the 15/17 translocation.

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  • OGAWA Kazuei
    The First Department of Internal Medicine, Fukushima Medical College
  • SHINEHA Haruko
    The First Department of Internal Medicine, Fukushima Medical College
  • ABE Rokuo
    The First Department of Internal Medicine, Fukushima Medical College
  • SHICHISHIMA Tsutomu
    The First Department of Internal Medicine, Fukushima Medical College
  • KIMURA Hideo
    The First Department of Internal Medicine, Fukushima Medical College
  • YUI Tokuo
    The First Department of Internal Medicine, Fukushima Medical College
  • KAWAGUCHI Michiko
    The First Department of Internal Medicine, Fukushima Medical College
  • MATSUDA Shin
    The First Department of Internal Medicine, Fukushima Medical College
  • UCHIDA Tatsumi
    The First Department of Internal Medicine, Fukushima Medical College
  • KARIYONE Shigeo
    The First Department of Internal Medicine, Fukushima Medical College

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Other Title
  • ＲＡＥＢ　ｉｎ　ｔｒａｎｓｆｏｒｍａｔｉｏｎの時期を経て発症した急性前骨髄球性白血病

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Description

A 34-year old female was admitted to our clinic because of fever and general fatigue on March 26, 1987. On admission, peripheral blood (PB) revealed pancytopenia. Bone marrow smears revealed 9.0% of promyelocytic cells with or without Auer rods. Diagnosis of RAEB in transformation was made. Chromosome study of the bone marrow cells showed t(15;17) in 3 out of 20 cells analysed. After 3 months, the leukemic cells were observed in PB and increased in number. Then the patient showed bleeding tendency and fibrin degradation products (FDP) increased up to 40 μg/ml. And the leukemic cells were over 30% in PB at the end of July, 1987. The diagnosis of APL with DIC was made.<br>To our knowledge, this is the first case of APL with a history of MDS with t(15;17).

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 30 (1), 67-71, 1989

    The Japanese Society of Hematology

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