Acute undifferentiated leukemia (stem cell acute leukemia) showing differentiation to Langerhans cell-like cells in lymph nodes

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  • FUKUTA Takanori
    Department of Pathology, Tottori Prefectural Central Hospital Department of Hematology, Tottori Prefectural Central Hospital
  • NAKAMOTO Shu
    Department of Pathology, Tottori Prefectural Central Hospital
  • HASHIMOTO Yoshinori
    Department of Hematology, Tottori Prefectural Central Hospital
  • TANAKA Takayuki
    Department of Hematology, Tottori Prefectural Central Hospital
  • TOKUYASU Yusuke
    Department of Pathology, Tottori Prefectural Central Hospital
  • MARUYAMA Junko
    Department of Hematology, Tottori Prefectural Central Hospital
  • OMURA Hiromi
    Department of Hematology, Tottori Prefectural Central Hospital
  • HINO Norihiko
    Department of Hematology, Tottori Prefectural Central Hospital
  • KUWAMOTO Satoshi
    Division of Molecular Pathology, Department of Microbiology and Pathology, University of Tottori
  • MURAKAMI Ichiro
    Department of Pathology, Medical course, Kochi University Medical School

Bibliographic Information

Other Title
  • リンパ節においてLangerhans cell様細胞への分化を示した未分化急性白血病（急性幹細胞白血病）
  • 症例報告 第55回日本血液学会中国四国地方会 会長推薦演題 リンパ節においてLangerhans cell様細胞への分化を示した未分化急性白血病(急性幹細胞白血病)
  • ショウレイ ホウコク ダイ55カイ ニホン ケツエキ ガッカイ チュウゴク シコク チホウカイ カイチョウ スイセン エンダイ リンパセツ ニ オイテ Langerhans cell ヨウ サイボウ エ ノ ブンカ オ シメシタ ミブンカ キュウセイ ハッケツビョウ(キュウセイ カンサイボウ ハッケツビョウ)

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Description

<p>A 75-year-old woman was referred to our hospital with suspected leukemia. Complete blood count demonstrated WBC 3,810/µl with 26% blasts, Hb of 11.7 g/dl and Plt of 18.0×104/µl. Bone marrow aspiration revealed blasts (86.3%) with expressions of CD34, CD7, TdT, CD33, and CD117. MPO was negative. Chromosomal analysis of the bone marrow showed isolated trisomy 10 in all leukemic cells (20/20). Swelling of superficial lymph nodes was also observed. Cervical lymph node biopsy revealed leukemic blasts which had the same phenotype as those in the bone marrow except that proliferation of Langerhans cell-like cells (LCs) was observed in the paracortex. LCs had pale cytoplasm and grooved nuclei, and were positive for both CD1a and S100 protein. Trisomy 10 was detected in both the leukemic blasts and the LCs by fluorescence in situ hybridization. This rare case strongly suggests leukemic cells to differentiate into LCs.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (1), 26-31, 2017

    The Japanese Society of Hematology

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