Current treatment strategies for newly diagnosed and relapsed APL

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  • EMI Nobuhiko
    Department of Hematology, Fujita Health University School of Medicine

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  • 初発および再発APLに対する治療
  • ショハツ オヨビ サイハツ APL ニ タイスル チリョウ

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Description

<p>Acute promyelocytic leukemia (APL) is defined by its characteristic morphology (AML FAB M3/M3v), specific chromosomal translocation t (15;17), and molecular correlates (PML/RARα). Treatment with all-trans retinoic acid (ATRA) combined with chemotherapy has a high cure rate. Clinical trials with arsenic trioxide (ATO) confirmed the efficacy of ATO for patients with relapsed APL. Recently, treatment with ATRA and ATO has been shown to result in high CR rates for the majority of patients with newly diagnosed APL. Many trials have been conducted to determine the optimal schedule for ATRA in combination with ATO.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (10), 1872-1877, 2017

    The Japanese Society of Hematology

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