18F-FDG-PET/CT is effective in distinguishing myelofibrosis due to bone marrow infiltration of diffuse large B-cell lymphoma from triple-negative primary myelofibrosis

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  • KUMAGAI Takuma
    Department of Hematology/Oncology, University of Yamanashi
  • SATOH Yoko
    PET Center/Department of Radiology, Kofu Neurosurgical Hospital
  • KOSHIISHI Megumi
    Department of Hematology/Oncology, University of Yamanashi
  • OOISHI Saori
    Department of Hematology/Oncology, University of Yamanashi
  • SUEKI Yuki
    Department of Hematology/Oncology, University of Yamanashi
  • NAKAJIMA Kei
    Department of Hematology/Oncology, University of Yamanashi
  • MITSUMORI Toru
    Department of Hematology/Oncology, University of Yamanashi
  • KIRITO Keita
    Department of Hematology/Oncology, University of Yamanashi

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Other Title
  • 18F-FDG-PET/CTがtriple negative原発性骨髄線維症との鑑別に有効であった骨髄浸潤を伴うびまん性大細胞型B細胞リンパ腫
  • 症例報告 18F-FDG-PET/CTがtriple negative原発性骨髄線維症との鑑別に有効であった骨髄浸潤を伴うびまん性大細胞型B細胞リンパ腫
  • ショウレイ ホウコク 18F-FDG-PET/CT ガ triple negative ゲンパツセイ コツズイ センイショウ ト ノ カンベツ ニ ユウコウ デ アッタ コツズイ シンジュン オ トモナウ ビマンセイ ダイ サイボウガタ B サイボウ リンパシュ

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Description

<p>Although myelofibrosis is mainly associated with myeloproliferative neoplasms (MPN), especially primary myelofibrosis (PMF), a variety of hematological malignancies, including acute myeloid leukemia, multiple myeloma and malignant lymphoma, also cause myelofibrosis with markedly varying degrees of severity. Thus, it is extremely important to accurately diagnose the underlying diseases that cause fibrosis in bone marrow. Analyses of JAK2, MPL and calreticulin gene mutations are useful for distinguishing MPN from other diseases, since 90% of MPN patients have a mutation in one of these genes. However, 10% of PMF patients do not have mutations in any of these genes, and these patients have a disease known as triple negative PMF. It is sometimes difficult to accurately distinguish triple negative PMF from secondary myelofibrosis caused by other diseases. Herein, we present a case of diffuse large B cell lymphoma (DLBCL) with bone marrow involvement, mimicking triple negative primary myelofibrosis. 18F-FDG-PET was useful for correctly diagnosing DLBCL.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (3), 228-232, 2017

    The Japanese Society of Hematology

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