Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis during pregnancy

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  • IKEDA Masahiro
    Division of Hematology, Japanese Red Cross Medical Center
  • OBA Rina
    Division of Hematology, Japanese Red Cross Medical Center
  • YOSHIKI Yumiko
    Division of Hematology, Japanese Red Cross Medical Center
  • SHINGAKI Sumito
    Division of Hematology, Japanese Red Cross Medical Center
  • TAKEI Tomomi
    Division of Hematology, Japanese Red Cross Medical Center
  • MIYAZAKI Kanji
    Division of Hematology, Japanese Red Cross Medical Center
  • ABE Yu
    Division of Hematology, Japanese Red Cross Medical Center
  • TSUKADA Nobuhiro
    Division of Hematology, Japanese Red Cross Medical Center
  • ISHIDA Tadao
    Division of Hematology, Japanese Red Cross Medical Center
  • SUZUKI Kenshi
    Division of Hematology, Japanese Red Cross Medical Center Myeloma and AL Amyloidosis Center, Japanese Red Cross Medical Center

Bibliographic Information

Other Title
  • 妊娠中に発症したEBウイルス関連血球貪食症性リンパ組織球症
  • 症例報告 第4回日本血液学会関東甲信越地方会 優秀演題 妊娠中に発症したEBウイルス関連血球貪食症性リンパ組織球症
  • ショウレイ ホウコク ダイ4カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ユウシュウ エンダイ ニンシン チュウ ニ ハッショウ シタ EB ウイルス カンレン ケッキュウドンショクショウセイ リンパ ソシキキュウショウ

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Abstract

<p>An 11-week pregnant, 32-year-old Japanese woman who had recovered from infectious mononucleosis visited our center due to fever, anorexia, and bilateral hypochondrial pain. Blood tests revealed leukopenia, thrombocytopenia and elevated ferritin. She was diagnosed with hemophagocytic lymphohistiocytosis (HLH). A high viral load of the Epstein-Barr virus (EBV) was recognized, indicating EBV-HLH. She was treated with a single dose of dexamethasone to protect the fetus. However, the disease was uncontrollable, necessitating etoposide and cyclosporine administration. Remission was obtained with these medications, and she has remained in remission for the 10 months since completion of chemotherapy. Although the occurrence of EBV-HLH during pregnancy is rare, it is possible that a change in cellular immunity associated with the pregnancy may contribute to EBV-HLH development.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (3), 216-221, 2017

    The Japanese Society of Hematology

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