An experience of administration of modafinil for excessive daytime sleepiness in a patient with myotonic dystorophy

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  • Suzuki Mikiya
    Department of Neurology, National Center Hospital of Neurology and Psychiatry Department of Neurology, National Higashisaitama Hospital
  • Oya Yasushi
    Department of Neurology, National Center Hospital of Neurology and Psychiatry
  • Kawai Mitsuru
    Department of Neurology, National Center Hospital of Neurology and Psychiatry Department of Neurology, National Higashisaitama Hospital

Bibliographic Information

Other Title
  • 筋強直性ジストロフィー患者の日中過眠に対するｍｏｄａｆｉｎｉｌ投与経験～その効果と副作用～
  • キン ゴウチョクセイ ジストロフィー カンジャ ノ ニッチュウ カミン ニ タイスル modafinil トウヨ ケイケン ソノ コウカ ト フクサヨウ

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Abstract

We report the beneficial and adverse effects of modafinil for daytime sleepiness in a 62-year-old female patient with myotonic dystrophy. Although it was effective for excessive daytime sleepiness, orolingual dyskinesia appeared the day following administration of modafinil (100mg/day), and dyskinesia disturbed her daily life including dental treatment. When modafinil was stopped, dyskinesia was improved. However, excessive daytime sleepiness deteriorated gradually; re-treatment with smaller dosage (50mg every other day) resulted in partial improvement but aggravation of both dyskinesia and diabetes mellitus. Modafinil should be administered carefully when the patient is older or has complications such as glucose intolerance.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 50 (8), 578-580, 2010

    Societas Neurologica Japonica

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