<i>Ex vivo</i> expansion of human cord blood hematopoietic stem cells using small-molecule compounds

DOI Web Site PubMed
  • IWAMA Atsushi
    Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University

Bibliographic Information

Other Title
  • 低分子化合物による造血幹細胞の体外増幅の可能性
  • テイブンシ カゴウブツ ニ ヨル ゾウケツ カンサイボウ ノ タイガイ ゾウフク ノ カノウセイ

Search this article

Abstract

Recent studies of hematopoietic stem and progenitor cells (HSPCs) have led to the development of new ways to detect and purify HSPCs and have also revealed several intrinsic and extrinsic factors that control the molecular signals fundamental to self-renewal and differentiation of HSPCs. These findings have provided new approaches for expanding HSPCs ex vivo utilizing protein factors and small-molecule compounds (SMCs) and have also demonstrated promising outcomes in clinical trials. Although further technical innovation is still needed, elucidation of the whole picture of signaling pathways critical to HSPCs and manipulation of such pathways by SMCs could establish efficient and robust methods for ex vivo expansion of HSPCs.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (8), 1011-1015, 2015

    The Japanese Society of Hematology

Keywords

Details 詳細情報について

Report a problem

Back to top