Systemic organ invasion accompanied by immunophenotypic change observed in extraosseous plasmacytoma

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  • TOKITA Katsuya
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
  • NAKAMURA Yukitsugu
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
  • ISO Hisako
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
  • NAKAMURA Yuko
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
  • SASAKI Ko
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine
  • MITANI Kinuko
    Department of Hematology and Oncology, Dokkyo Medical University School of Medicine

Bibliographic Information

Other Title
  • 免疫学的形質の変化に伴い全身臓器への浸潤を認めた骨外性形質細胞腫
  • メンエキガクテキ ケイシツ ノ ヘンカ ニ トモナイ ゼンシン ゾウキ エ ノ シンジュン オ ミトメタ ホネ ガイセイ ケイシツ サイボウ シュ

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Abstract

We report a 57-year-old man who was diagnosed based on morphological findings as having extraosseous plasmacytoma of the left lower eyelid. Tumor cells were positive not only for CD38 and CD138, but also for CD19 and surface immunoglobulin lambda chain. He obtained a complete remission with irradiation and VAD therapy, but the disease relapsed one year later in the testis and popliteal fossa. Because tumor cells appeared to be blastoid, CHOP therapy was administered, and the patient achieved a temporary remission. Cytoplasmic lambda chain-positive and CD19-negative tumors eventually recurred at multiple sites including the central nervous system but not in the bone marrow. Treatment with the BD regimen and lenalidomide failed, and he died four years after the initial diagnosis.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (1), 56-59, 2016

    The Japanese Society of Hematology

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