Two Fatal Cases of Aplastic Anemia Probably Induced by Gold Salt Therapy

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  • YAMAUCHI Katsuyo
    Third Department of Internal Medicine Yamaguchi University School of Medicine
  • INOUE Masamitsu
    Third Department of Internal Medicine Yamaguchi University School of Medicine
  • ODA Susumu
    Third Department of Internal Medicine Yamaguchi University School of Medicine
  • MATSUMOTO Noboru
    Third Department of Internal Medicine Yamaguchi University School of Medicine
  • MIWA Shiro
    Third Department of Internal Medicine Yamaguchi University School of Medicine

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  • 金製剤により発症したと思われる再生不良性貧血の2死亡例
  • キン セイザイ ニ ヨリ ハッショウシタ ト オモワレル サイセイ フリョウセ

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Abstract

Two fatal cases of aplastic anemia which developed after administration of gold salt for the treatment of rheumatoid arthritis were reported. The frst case was a 58-year-old female who had received aurothioglucose 390 mg totally during the period of 5 months. On admission, serere pancytopenia (platelet 7000/mm3, leucocyte count 900/mm3 with 1% nuetrophil) was noted. No recovery was obtained in spite of anabolic steroid therapy and she expired on the 15th hospital day from septicemia and intracranial bleeding. The second case was a 43-year-old housewife who had received sodium aurothiomalate 600mg totally during the period of 8 months. And then bleeding tendency developed. She had marked pancytopenia (Hb 5.0g/dl, leucocyte count 1200/mm3 with 6% neutrophil, platelet 8000/mm3) and severe hypoplastic bone marrow. Any treatment, including BAL, lithium, and anabolic steroid, failed to improve bone marrow findings. She died four months later due to septicemia and subarachnoidal hemorrhage.<br>As far as we reviewed the recent literatures, 14 cases of aplastic anemia induced by gold salt therapy have been reported. The mortality rate was high (64.3%).

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 20 (11), 1467-1474, 1979

    The Japanese Society of Hematology

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