Anti-Ma2, anti-NMDA-receptor and anti-GluRε2 limbic encephalitis with testicular seminoma: short-term memory disturbance

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  • Kubota Akihiro
    Department of Neurology, Saitama Medical Center, Saitama Medical University
  • Tajima Takashi
    Department of Neurology, Saitama Medical Center, Saitama Medical University
  • Narukawa Shinya
    Department of Neurology, Saitama Medical Center, Saitama Medical University
  • Yamazato Masamizu
    Department of Neurology, Saitama Medical Center, Saitama Medical University
  • Fukaura Hikoaki
    Department of Neurology, Saitama Medical Center, Saitama Medical University
  • Takahashi Yukitoshi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
  • Tanaka Keiko
    Department of Neurology, Kanazawa Medical University
  • Shimizu Jun
    Department of Neurology, University of Tokyo, Graduate School of Medicine
  • Nomura Kyoichi
    Department of Neurology, Saitama Medical Center, Saitama Medical University

Bibliographic Information

Other Title
  • 短期記憶障害を呈し抗Ma2抗体，抗NMDAR抗体，抗GluRε2抗体陽性で，後に精巣腫瘍をみとめた傍腫瘍性辺縁系脳炎の1例
  • 症例報告 短期記憶障害を呈し抗Ma2抗体,抗NMDAR抗体,抗GluRε2抗体陽性で,後に精巣腫瘍をみとめた傍腫瘍性辺縁系脳炎の1例
  • ショウレイ ホウコク タンキ キオク ショウガイ オ テイシ コウMa2 コウタイ,コウNMDAR コウタイ,コウGluRe2 コウタイ ヨウセイ デ,アト ニ セイソウ シュヨウ オ ミトメタ ボウ シュヨウセイ ヘンエンケイ ノウエン ノ 1レイ
  • Anti-Ma2, anti-NMDA-receptor and anti-GluR^|^epsilon;2 limbic encephalitis with testicular seminoma: short-term memory disturbance

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Abstract

A 36-year-old man presented with cognitive impairment and disturbance of short-term memory functions with character change. Cerebrospinal fluid analysis revealed no abnormalities; however, brain MRI revealed high-signal intensity from bilateral hippocampus lesions on fluid attenuated inversion recovery (FLAIR) images and T2 weighted images. The 18F-fluorodeoxyglucose PET demonstrated high glucose uptake in the bilateral hippocampus lesions. He was diagnosed as limbic encephalitis, and was administered high-dose intravenous methylprednisolone and immune adsorption plasma therapy followed by intravenous immunoglobulin therapy. MRI abnormalities improved after treatment but recent memory disturbance remained. Ma2 antibody, NMDA-receptor antibody, and GluRε2 antibody were positive. Eleven months atter the onset of disease, the tumor was identified in left testicle by ultrasound and removed the tumor. The pathological findings were seminoma. We experienced a case of paraneoplastic limbic encephalitis associated with seminoma with short-term memory disturbance. The occurrence of paraneoplastic limbic encephalitis with antibodies against cell membrane (NMDA-receptor antibody and GluRε2 antibody) and intracellular (Ma2 antibody) is rare even in the literature.<br>

Journal

  • Rinsho Shinkeigaku

    Rinsho Shinkeigaku 52 (9), 666-671, 2012

    Societas Neurologica Japonica

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