Acute myeloid leukemia with t (3;8) (q26.2;q24), a simple variant of 3q26.2/<i>EVI1</i> translocation

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  • SATO Kazuyuki
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • SAKAI Hirotaka
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • UCHIDA Akiko
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • UEMURA Yu
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • TSURUOKA Yuka
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • YOKOI Satoshi
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • NISHIO Yuji
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • MATSUNAWA Manabu
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • SUZUKI Yoshinori
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • ISOBE Yasushi
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • KATO Masayuki
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • TOMITA Naoto
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • INOUE Yasuyuki
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine
  • MIURA Ikuo
    Department of Internal Medicine, Division of Hematology and Oncology, St. Marianna University School of Medicine

Bibliographic Information

Other Title
  • 3q26.2/<i>EVI1</i>の単純変異転座t (3;8) (q26.2;q24)を伴う急性骨髄性白血病
  • 症例報告 第5回日本血液学会関東甲信越地方会 奨励賞 3q26.2/EVI1の単純変異転座t(3;8)(q26.2;q24)を伴う急性骨髄性白血病
  • ショウレイ ホウコク ダイ5カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ショウレイショウ 3q26.2/EVI1 ノ タンジュン ヘンイテンザt(3;8)(q26.2;q24)オ トモナウ キュウセイ コツズイセイ ハッケツビョウ

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Abstract

<p>A 70-year-old man with pancytopenia was referred to our hospital. His bone marrow comprised 75.4% leukemic blast cells and increased micromegakaryocytes. The leukemic cells were positive for myeloperoxidase and expressed CD2, CD13, CD33, CD34, CD56, CD117, HLA-DR, and MYC. Chromosomal analysis revealed 45,XY,t (3;8) (q26.2;q24),-7[6]/46,XY[14]. Fluorescence in situ hybridization revealed the rearrangement of the ecotropic viral integration site 1 (EVI1) gene. Thus, the patient was diagnosed as having acute myeloid leukemia (AML) with maturation, according to the WHO classification; he achieved complete cytogenetic remission after two courses of combination chemotherapy using anthracyclines and cytarabine. The t (3;8) translocation is a rare simple variant of the 3q26.2/EVI1 translocation, which is an adverse prognostic factor of AML. Clarifying the clinical features of leukemia in patients with simple variant translocations facilitates the development of therapies.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 58 (4), 315-322, 2017

    The Japanese Society of Hematology

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