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Pre-critical MRI findings of an Alzheimer’s disease patient with pathologically proven cerebral amyloid angiopathy related lobar hemorrhage
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- Nonaka Toshihiro
- Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine
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- Yakushiji Yusuke
- Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine
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- Ide Toshihiro
- Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine
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- Ito Hiroshi
- Department of Neurosurgery, Saga University Faculty of Medicine
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- Kawamoto Kazuhiro
- Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine
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- Hara Hideo
- Division of Neurology, Department of Internal Medicine, Saga University Faculty of Medicine
Bibliographic Information
- Other Title
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- 発症前に多彩な脳アミロイドアンギオパチー関連MRI所見が描出されていたアルツハイマー病合併脳葉型出血の1例
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Description
An 85-year-old woman with untreated hypertension was admitted with a disturbance of consciousness. On admission, brain CT revealed a lobar intracerebral hemorrhage with a midline shift. An intracranial hematoma was evacuated via a life-saving craniotomy. Definite pathological findings of amyloid-β deposition in the excised hematoma (strong in anti-amyloid β40 immunostain, but weak in anti- amyloid β42) indicated cerebral amyloid angiopathy (CAA). She had been diagnosed with Alzheimer’s disease at a regional memory clinic one month before symptom onset based on MRI findings of medial temporal lobe atrophy as well as CAA-related features of multiple strictly lobar cerebral microbleeds in the occipital lobe, cortical superficial siderosis and >20 enlarged perivascular spaces in the centrum semiovale. This experience suggests that comprehensive interpretation of such CAA-related findings on MRI might help to improve the management of cardiovascular risk factors for Alzheimer’s disease.
Journal
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- Rinsho Shinkeigaku
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Rinsho Shinkeigaku 56 (5), 338-343, 2016
Societas Neurologica Japonica
