軽症血友病A患者に対する1-Deamino-8-D-Arginine Vasopressinの臨床応用

DOI Web Site PubMed 被引用文献1件

書誌事項

タイトル別名
  • Clinical Application of 1-Deamino-8-D-Arginine Vasopressin to Mild Hemophilia A
  • ケイショウ ケツユウビョウ A カンジャ ニ タイスル 1 Deamino 8

この論文をさがす

抄録

The replacement therapy of AHG on hemorrhagic episode in hemophilia A patients have faced several troublesome complications, i.e., appearance of inhibitor, hepatitis and allergic reaction.<br>After obtaining that 1-Deamino-8-D-Arginine Vasopressin (DDAVP) increased factor VIII activity in normal subjects, the usefulness of this drug to these patients was evaluated.<br>Intravenous infusion of 10μg DDAVP to seven normal subjects and to four mild hemophilia A patients were monitored serially by coagulation and fibrinolysis studies. In normal subjects, factor VIII activity increased from 2 to 5 times, factor VIII antigen from 1.6 to 2.7 times. In four mild hemophiliacs, factor VIII activity increased from 2.2 to 3.3 times. Because the plasminogen activator increments were observed in both normal and hemophiliacs, antiplasmic agent to block the fibrinolytic activity was accompanied to the DDAVP infusion (0.4 g/Kg, every 12 hours) in clinical practice. For gastrectomy, AHG was used in addition to the DDAVP to supply the factor VIII level needed for major operation.<br>For tooth-extraction, only DDAVP was used. In both cases, the hemostatic effect of this DDAVP was prominent and satisfactory.<br>On the 5th operation day, however, hyponatremia was observed and DDAVP was withdrawn.<br>DDAVP appeared to be a very useful tool in controlling hemostasis in mild hemophiliacs in hyponatremia was carefully watched.

収録刊行物

  • 臨床血液

    臨床血液 19 (12), 1614-1621, 1978

    一般社団法人 日本血液学会

被引用文献 (1)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ