Reevaluation on the Severity and Prognostic Factors in Aplastic Anemia

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  • HOTTA Tomomitsu
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • HIRABAYASHI Noriyuki
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • UTSUMI Makoto
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • TAKITA Motonari
    1st Department of Internal Medicine, Nagoya University School of Medicine
  • YAMADA Hideo
    1st Department of Internal Medicine, Nagoya University School of Medicine

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Other Title
  • 再生不良性貧血の重症度と予後の再検討
  • サイセイ フリョウセイ ヒンケツ ノ ジュウショウド ト ヨゴ ノ サイケント

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Abstract

The survival and its correlation with initial hematologic values of 169 patients with aplastic anemia were analysed in this study. According to survival terms, these patients could be divided into 3 groups: short-term (≤6 months), intermediate (6 months-5 years) and long-term (≥5 years) survivors. The correlation between the survival terms of the patients and their initial hematologic values were analysed and the usefulness of individual and integrative indices of initial hematologic values (reticulocytes≥1×104/cmm:1, neutrophils≥500/cmm:1, platelets≥3×104/cmm:0.5, and the percentage of hemopoietic cells in bone marrow≥30%:1.5) as prognostic indices was evaluated.<br>The integrative score of initial hematologic values was found to be a best prognostic indices. According to the integrative score, the severity of the disease was classified into 3 groups: severe (score 0∼2), moderate (score 2.5∼3.5) and mild (score 4).<br>As the patients with score 1 or less have extremely poor prognosis under the conventinal treatment, bone marrow transplantation will be recommended as an another therapeutic approach for these patients at this time, if they have a HLA compatible donor(s).

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 19 (12), 1634-1640, 1978

    The Japanese Society of Hematology

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