Relationship between cardiac 123I-metaiodobenzylguanidine scintigraphy and cardiovascular autonomic function test (standing test) in Parkinson's disease

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  • Doi Hideki
    Department of Neurology, Higashi General Hospital of Nagoya Department of Neurology, Nagoya University School of Medicine
  • Niimi Yuki
    Department of Neurology, Higashi General Hospital of Nagoya
  • Hasegawa Yasuhiro
    Department of Neurology, Higashi General Hospital of Nagoya Department of Neurology, Nagoya Daini Red Cross Hospital
  • Miwa Shigeru
    Department of Neurology, Higashi General Hospital of Nagoya
  • Yamana Tomoko
    Department of Neurology, Higashi General Hospital of Nagoya
  • Takagi Susumu
    Department of Neurology, Higashi General Hospital of Nagoya Jousai General Hospital of Nagoya
  • Takahashi Akira
    Department of Neurology, Tokai Central Hospital
  • Sobue Gen
    Department of Neurology, Nagoya University School of Medicine

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Other Title
  • パーキンソン病における｀１２３´Ｉ‐ＭＩＢＧ心筋シンチグラフィと起立負荷試験の関連性
  • パーキンソン病における123I-MIBG心筋シンチグラフィと起立負荷試験の関連性
  • パーキンソンビョウ ニ オケル 123I MIBG シンキン シンチグラフィ ト キリツ フカ シケン ノ カンレンセイ

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We investigated the correlation between results of 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy and those of cardiovascular autonomic function tests in patients with Parkinson's disease (PD). 123I-MIBG myocardial scintigraphy and a 5-minute standing test were performed in 50 patients with PD and in 19 control subjects. The value of the basal plasma noradrenaline (NA) level was used as an index of basal sympathetic nerve activity, and %NA was used to assess the response of sympathetic nerve activity. In addition, the parameters of Δ BP and Δ HR were evaluated to assess the autonomic response of the cardiovascular system. A mild, but significant correlation was observed between the myocardium to mediastinum (H/M) ratio and the values of the plasma NA baseline (r=0.35, p<0.05 in early image, r=0.29, p<0.05 in delay image). No significant correlation was observed between the H/M ratio and the other parameters (%NA, Δ BP, Δ HR). These results suggest that 123I-MIBG myocardial scintigraphy may be associated with the basal sympathetic nerve activity, but not with autonomic nervous response of the cardiovascular system in patients with PD.<br>

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