Aplastic Anemia Treated by Isogeneic or Allogeneic Bone Marrow Transplantation

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  • HARADA Mine
    Blood Transfusion Section, Kanazawa University School of Medicine
  • KITAO Takeshi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • SUGIYAMA Tatsuro
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • KODO Hideki
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • OTAKE Shigeki
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • OKAFUJI Kazuhiro
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • YOSHIDA Takashi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • FUNADA Hisashi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • TSUKUDA Koji
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • ISHINO Chizuko
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • MORI Takao
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • FUJITA Shinichi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • ISHIZAKI Takeshi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • NIWA Kazuo
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • MITAMURA Eiichi
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • MATSUE Kosei
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • HISADA Tomoichiro
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • NAKAMURA Shinobu
    Third Department of Internal Medicine, Kanazawa University School of Medicine
  • HATTORI Kenichi
    Third Department of Internal Medicine, Kanazawa University School of Medicine

Bibliographic Information

Other Title
  • 再生不良性貧血に対する同系および同種骨髄移植の試み
  • サイセイ フリョウセイ ヒンケツ ニ タイスル ドウケイ オヨビ ドウシュ コツズイ イショク ノ ココロミ

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Abstract

Isogeneic or allogeneic bone marrow transplantation was tried for the treatment of three cases with aplastic anemia. Case 1, a 19-year-old woman, was infused twice with 2.8×109 and 4.25×109 bone marrow cells respectively from her healthy identical twin. However, post-transplantation recovery in hematologic values was not observed. Case 2, a 10-year-old boy, also received an isogeneic graft twice from his identical twin. In spite of grafting an adequate dose of marrow cells (3.5×108/kg) and a transient increase in reticulocyte count, a complete hemopoietic recovery was not obtained. Therefore, there is a possibility that stem cell replacement might be ineffective in these cases. Case 3, a 28-year-old woman, was found to be compatible in ABO and HLA-A, B, D. Then, allogeneic marrow grafting was carried out by infusing 13.6×109 cells from one of these HLA-identical and MLC-nonreactive siblings with the use of an isolation room and the sterilizing regimen (“GVN”). Although both engraftment and GVHD were not observed, a febrile episode was treated by antibiotics and granulocyte transfusions, and hemopoiesis recovered to the pretransplantation level after three months. This case suggests that sterilization and intensive supportive therapy may be of primary importance for lifethreatening myelosuppression by high-dose chemotherapy. In addition, major histocompatibility complex and immune mechanism in aplastic anemia were discussed in association with bone marrow transplantation.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 19 (11), 1509-1518, 1978

    The Japanese Society of Hematology

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