Basic understanding of the HLA system in allogeneic hematopoietic cell transplantation

  • ICHINOHE Tatsuo
    Department of Hematology and Oncology, Hiroshima University Hospital Research Institute for Radiation Biology and Medicine, Hiroshima University

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Other Title
  • 造血細胞移植におけるHLAの基礎知識
  • ゾウケツ サイボウ イショク ニ オケル HLA ノ キソ チシキ

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Description

Human immune responses are principally characterized by the human leukocyte antigen (HLA) system, a diverse set of cell surface molecules encoded by the major histocompatibility complex gene cluster on the short arm of chromosome 6. Among various members of the HLA family, the best characterized are the classic highly polymorphic class I and class II molecules that are responsible for antigen presentation to T cells and regulation of NK cell functions. In allogeneic hematopoietic cell transplantation, sophisticated approaches to donor-recipient allele-level matching at 3 class I (HLA-A/B/C) and 3 class II (HLA-DRB1/DQB1/DPB1) loci have been proven to lower the risk of immunologic complications such as graft failure and graft-versus-host disease, and possibly to confer effective graft-versus-malignancy effects. Future areas of research include clarifying the role of relatively non-polymorphic non-classical HLA molecules (HLA-E/F/G, HLA-DM/DO) and polymorphic/non-polymorphic class I-related molecules (MICA, MICB, HFE, MR1, CD1, FcRn) in the immune regulation that follows hematopoietic cell transplantation.

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 56 (10), 2134-2143, 2015

    The Japanese Society of Hematology

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